Shizune (シズネ,Shizun) is the assistant of Tsunade and a talented Medic-nin. She left Konoha with Tsunade after her uncle, Dan, died, and trained under Tsunade for many years afterwards. Shizune is quite close to Tsunade, being one of the few people Tsunade will trust with absolute certainty. Unlike Tsunade, Shizune is level-headed, practical, and a rational thinker. As a result, she tends to stress over details like Tsunade's tendency to gamble and think with her heart. She often gets comically worked up over any irrational decision Tsunade makes, particularly her making large bets. Shizune also looks after Tonton, Tsunade's pet pig.