The three most popular Uchiha from alot of convos on the base seem to be Sasuke, Madara, then Itachi.
Notice all three specialize in what i call the Susano'o triangle. You need Amateratsu(sasuke) and Tsukiyomi(Itachi) to make Susano'o( Madara).
Sasuke so far has become the best in using Amateratsu.
Itachi's Tsukiyomi is unsurpassed.
Madara and his various Susano'o are just badass.
All three of them specialize in a certain aspect in that triangle which makes me think they are directly related instead of Madara just being an ancestor.
That and the fact that Sasuke and Izuna look almost identical.
This could be a reason Kurama compared Sasuke's chakra to Madara. Family tends to have the same chakra type ( Kushina and naruto)
Also with Sasuke being a direct descendent to Madara. no one better is suited to hold the curse of hatred.