Breaking the Cycle of Hatred
When the Sage of 6 Paths died, he picked one of his two sons to be his heir. In most "real" cases, the oldest son should have become the heir. However, the Sage picked the younger son because the younger son had better ideals. This started the cycle of hatred, because the son who should have become the leader (the older one, the Uchiha) did not, but the son who should not have been the leader (the younger one, the Senju) did.
Hashirama offered the job of the first hokage to Madara. Madara looked like he was happy to have the job. However later Tobirama said that the people should decide, and the people decided against Madara. Again, the person who should have been in charge (Madara, the uchiha) did not, while the person who did not want to be in charge (Hashirama, the Senju) did.
Arguably there's another smaller event with Itachi and Danzo. Hiruzen said that Itachi "thought like a hokage". This suggests that Itachi could have been considered for that position if the Uchiha weren't planning a coup and if Danzo didn't talk him into performing the massacre. Itachi, who probably should have become hokage one day was instead turned into a criminal, while Danzo (who definitely should not have been hokage), eventually became the acting Hokage while tsunade was in a coma. (If you want to be picky and point out that Danzo wasn't a hokage, I can mention that Tsunade IS a Senju, and she became the fifth hokage when Itachi might have been considered for the position, if he wasn't a criminal).
That is 3 times that the cycle of hatred has continued. Each time there is a real opportunity for an Uchiha to be recognized by everybody as a hero and a leader, but instead a Senju has taken the position.
Now we're coming to a critical moment in the story: Sasuke is coming to the battlefield on the side of the allies. There is another opportunity for this cycle to be broken. In the end, if Sasuke is redeemed as a hero, the obvious choice will be between Sasuke and Naruto to become the next hokage. Naruto is obviously a major hero of the war and well-liked by everybody. Sasuke is leading a powerful team to come help as well. Both will be seen as heroes in the end.
Naruto will suggest to Sasuke that he should be the next hokage, and protect the village (and therefore protect Itachi's dream and honor Itachi and the Uchiha). Somebody will suggest that the people should instead decide (and the people will probably choose Naruto). There are two options:
1) Naruto accepts. He becomes hokage. Sasuke is snubbed and the cycle of hatred continues for the next generation.
2) Naruto declines. Naruto insists that Sasuke becomes the next hokage. Sasuke does become the hokage, the Uchiha are redeemed and the cycle of hatred is broken forever.
Kishi has been foreshadowing this issue quite a lot, and I think option #2 is what will happen in the end of the manga. Thoughts?