Sasuke will fight Madara 1 on 1
During the war arc ,Sasuke did not fight technically.Sasuke rested from all the fight against dediara to danzo and team 7.I believe the Jubi jutsu will make everyone unconcious while sasuke squad take over the rest of the battle.
Madara have rinnegan ,mokutan,EMS ,senju dna and alot of knowledge which will give him an advantage against the edo kages.Rinnegan will give Madara access to all the ninjutsu available and ying yang release which will counter any jutsu hiruzen throw at him.Hashirama and Madara faught many times during their lifetime,Madara know/copy all his jutsus and he will be able to counter them with easy.Tobirama so far can use water release,ftg and edotensi .Tobirama ftg clan be counter by susano,idk what edo tensi summon tobirama had in the past but i sure it will be out class by Current Madara.Minato should be very predictable in battle if he only use resengan and ftg with his kunai.However Minato have ying Kurama in him,idk if he will use the ying chakra or give Naruto when they meet but Madara is fimilar with Kurama capabilities from the past.
Sasuke on the other hand have amaterasu (which have not been display by Madara),Susano arrow (which we have not seen it full capabilities),Blaze release (which we have not seen it full capabilities) and his unknown jutsu.We donot know what EMS grant Sasuke but we know EMS give a fourth power (which can by any random power up ocular jutsu ).Sasuke have not shown fearful to join the battle field where Madara located,I guess he is confident of his capabilities.We knew Sasuke is very clever and he will think ahead to know which jutsu best suited against Madara who been known as most fear and powerful ninja in the series.Probably Sasuke stress in battle against Madara will allow him to unlock other jutsu or Itachi power (yata mirror and totsuka blade ) will give him an upper hand.
We just have to wait and see i guess