I used the Search, didn't find anything. But sorry if this has been made before.
Tsunade... is she half Uzumaki? Her grandmother is Mito Uzumaki, the wife of the First Hokage. That means she must have some Uzumaki blood in her, right?
On a side, less imp note, she and Mito have the same diamond marking on their forehead xD
If someone could explain more, I'd be grateful. I'm confused right now :/