Hashirama Senju < Nagato Uzumaki
1) Summonings are Immobile once their eyesight is blocked
After Itachi Blocked nagato's Summons, they were rendered useless and not used again.
Nagato's Maneuverable abilitly is very limited, his reflexes dont go much further than kakashi...hence the reason why Linked vision is his Main source of Evasion.
As opposed to Hashirama's mokuton, It's growth rate is mind blowing, as seen here when sarutobi jumped:
To a small forest before he completed his jump:
3) Nagato has shown not shown the ability to regenerate wounds
Flower Tree World
-----------------------------How Hashirama Counters Nagato's Techniques-----------------------------------
1) Banshō Ten'in and Shinra Tensei
Mokuton could easily keep hashirama grounded from BT and as for ST, it could be used as a shield.
2) Chibaku Tensei
As shown in the second scan above, Mokuton easily Break's through Rock/earth.
Mokuton also can be used to keep Hashirama grounded to the earth. Some argue and say that what ever earth hashirama is grounded to CT would just suck it up.
It all depends on The size.
The CT Deva path created didn't abosorb All the surrounding Earth, it took a large portion of it. And lets not forget the fact that that hashirama could manuver his mokuton to carry him to a dfferent location much like shockwave from transformers.
This is debatable weather or not it would be successful against hashirama, but the chances are low.
3) Summoning Technique: Gedo Mazou + Dragon Soul Removal
Bear in mind, Nagato's time limit using this technique is his life.
During his fight against hanzou, he used the technique for around 30-45 seconds and it put him in this state:
If Hashirama can evade the the technique for enough time, Either nagato will die from his lifefoce and chakra being absorbed (causing the gedo to automatically reverse summon) or He'll be forced to cancel the technique in order to save his life placing him in a state of the picture above.
Other Methods by which Hashirama could could counter this:
1) Use Mokuton at long range to break Chakra rods between Nagato and the Gedo
2)Attack/over power the gedo directly with mokuton.
3)A reverse summon - a commonly known technique by any ninja above fodder level (like the one hanzo used) could be used by hashirama to evade this also.
4) Celestrial Tera Blast
CTB - Destroyed the Entire Village Of konoha.
Hashrama's Mokuton - Created the Entire Village Of konoha.
Being that those two statements ^ Are True, We can safty say that Hashirama Can infact Defend against CTB with his mokuton, at least at an equal scale.
5) Asura Path + Taijutsu
Hashirama fans, you can say thank you to chapter 605 which helped me to include this section in my analysis.
We should all be able to agree that Mokuton shashiki > Asura path
The Contract seal: When the user implements this fūinjutsu on a summoner, it removes any direct control the summoner has over a summoned creature
Also Mokuton over powers/crushes all of nagato's summonings.
7) The hated Much, Preta Path
First off, although a great speculation, Preta Path can indeed Absorb Mokuton simply because Yin chakra is "What gives it the Ability to move" and Preta path can absorb Senjutsu (natures chakra) so why not Yin chakra?
Problem is, From speculation The User Is opened for physical attacks while using Preta path simply because it requires Focus.
1)In the 6POP we saw preta path using both hands to perform the technique, and his focus seemed only on that.
2)Madara used A single hand to absorb Onooki's jinton from the direction in which it was coming.
3)Edo Nagato stopped using Preta Path in order to block Bee's attack
This could go either of both ways, if Hashirama physically attacked Nagato while he was busy using Preta path absorbing mokuton.
Conclusion: Hashirama Wins this High Difficulty.
p.s. This analysis did not include all of nagato's techniques, simply because they are useless against Hashirama's defenses, Techniques such as Wind Release: Air Bullets.