I was going through the manga, because I was bored and I found this page: http://www.narutobase.net/manga/Naruto/386/14
Throughout the manga Sasuke has been a foil to naruto: naruto's a loser and sasuke's cool, sasuke's a genius and naruto is a dropout, all the girls love Sasuke but find Naruto annoying... But the most important clash in their foil is the Senju vs Uchiha. They both went through tramatic childhoods, but have responded to it in different ways. http://www.narutobase.net/manga/Naruto/485/14
I personally think that there is no way that Sasuke isn't going to be redeemed somehow. I think that Sasuke is supposed to show that even though he was born into a clan cursed by hate, he can overcome his blood drenched fate and break the cycle of hate and redeem himself. I think this makes Sasuke much more interesting than Naruto, because right now Naruto is too perfect. While Naruto is putting the team on his back and fighting on every single battlefield at once, Sasuke is asking questions like this http://www.narutobase.net/manga/Naruto/592/1 and this http://www.narutobase.net/manga/Naruto/592/3
But back to the Senju vs Uchiha rivalry... I think having the whole manga focus on Naruto and Sasuke's bond shows that the cycle of hate can only be broken through bond's with other people, and Naruto and Sasuke's bond represents a bond which will overcome the greatest hatred/rivalry that the Uchiha feel toward the Senju.