Ok Genetics 101 for those who say Tsunade is half senju and half uzamaki. That would only be true if Mito and Hashi were her PARENTS, not Grandparents. Which ever one of Tsunade's parents that came from Hashi and Mito would be half and half. Tsunade would be half of what her mom is and half of what her dad is.
Example. Her mom hypothetically is daughter of Hashi and Mito. Her dad is justa regular guy, then Tsunade is 1/3 Uzamaki, 1/3 Senju and 1/3 average. Think about this... If a biracial child (african american and white) has a child with a white person. the resulting child is not half black and half white. That child is 3/4 white 1/4 black. Same with Tsunade. We need to know what her parents were to conclude on this topic.