Re: Orochimaru vs Tsunade
So here's what I think working under the the ideas provided by the databook. Their prowess in ninjutsu is the same albeit in they are strong in different areas. She is by far better at taijutsu in comparison to him. He is much better at casting genjutsu. They are of equal intellect. He is a whole tier faster than her. She has more stamina than him. He performs hand seals faster than she does.
My conclusion Tsunade would win
Edit: The edos might cause a problem but we know Tsunade has a form of fuinjutsu as per her seal on her forehead. Given the fact that she is the oldest living Uzumaki we know with actual connections to members of her clan she probably has other sealing jutsus.
But the edos do pose an interesting problem. Though she may be able to remove the talisman Oro used to control them when blow to their heads. At which point they'd help her.