Sasuke will learn the truth from the one who know everything about Uzumaki and Uchiha destruction and will get angry
On both Madara and obito and will join war alongside Naruto and he will tell everything about his clan (Uzumaki) destruction
And then both join together to fight Madara and Obito.
So Sasuke will take on Obito for killing his whole clan , while Naruto will take on Madara for killing his whole clan.

sharing my thought what yo think about it? :D