Ok, so we know these two gentleman think very lowly of each other's clans and both present a very arrogant personality.
Tobirama thinks of Uchihas as evil inferiors that must be caged, more or less.
Madara thinks that Senjus are the ugliest people if they are fodders.
Of course, if it came down to a brawl, Madara would turn Tobirama into a cleaning tool... But if they were to engage in a "My clan is superior to yours" debate, who do you think would win? :confused:
My money is on Tobirama- he'd piss Madara off bad.